Meniu
Asmeninė anketa Prisijungimas ir registracija
Atgal » » » 2020 » Lapkričio » 10

Researchers identify melatonin as possible COVID-19 treatment

Researchers identify melatonin as possible COVID-19 treatment

Results from a new Cleveland Clinic-led study suggest that melatonin, a hormone that regulates the sleep-wake cycle and is commonly used as an over-the-counter sleep aid, may be a viable treatment option for COVID-19.

As COVID-19 continues to spread throughout the world, particularly with cases rising during what some have termed the "fall surge," repurposing drugs already approved by the U.S. Food and Drug Administration for new therapeutic purposes continues to be the most efficient and cost-effective approach to treat or prevent the disease. According to the findings published today in PLOS Biology, a novel artificial intelligence platform developed by Lerner Research Institute researchers to identify possible drugs for COVID-19 repurposing has revealed melatonin as a promising candidate.

Analysis of patient data from Cleveland Clinic's COVID-19 registry also revealed that melatonin usage was associated with a nearly 30 percent reduced likelihood of testing positive for SARS-CoV-2 (the virus that causes COVID-19) after adjusting for age, race, smoking history and various disease comorbidities. Notably, the reduced likelihood of testing positive for the virus increased from 30 to 52 percent for African Americans when adjusted for the same variables.

"It is very important to note these findings do not suggest people should start to take melatonin without consulting their physician," said Feixiong Cheng, Ph.D., assistant staff in Cleveland Clinic's Genomic Medicine Institute and lead author on the study. "Large-scale observational studies and randomized controlled trials are critical to validate the clinical benefit of melatonin for patients with COVID-19, but we are excited about the associations put forth in this study and the opportunity to further explore them."

Here, the researchers harnessed network medicine methodologies and large-scale electronic health records from Cleveland Clinic patients to identify clinical manifestations and pathologies common between COVID-19 and other diseases. Specifically, they measured the proximity between host genes/proteins and those well-associated with 64 other diseases across several disease categories (malignant cancer and autoimmune, cardiovascular, metabolic, neurological and pulmonary diseases), where closer proximity indicates a higher likelihood of pathological associations between the diseases.

They found, for example, that proteins associated with respiratory distress syndrome and sepsis, two main causes of death in patients with severe COVID-19, were highly connected with multiple SARS-CoV-2 proteins. "This signals to us, then," explained Dr. Cheng, "that a drug already approved to treat these respiratory conditions may have some utility in also treating COVID-19 by acting on those shared biological targets."

Overall, they determined that autoimmune (e.g., inflammatory bowel disease), pulmonary (e.g., chronic obstructive pulmonary disease and pulmonary fibrosis) and neurological (e.g., depression and attention-deficit hyperactivity disorder) diseases showed significant network proximity to SARS-CoV-2 genes/proteins and identified 34 drugs as repurposing candidates, melatonin chief among them.

"Recent studies suggest that COVID-19 is a systematic disease impacting multiple cell types, tissues and organs, so knowledge of the complex interplays between the virus and other diseases is key to understanding COVID-19-related complications and identifying repurposable drugs," said Dr. Cheng. "Our study provides a powerful, integrative network medicine strategy to predict disease manifestations associated with COVID-19 and facilitate the search for an effective treatment."

Turite savo nuomone, (už ar, prieš) pasidalinkite su mumis, palikite komentarą, prisijunkite, rašykite bloge, pasirinkdami kategoriją. Pasidalinkite savo receptais, sveikatos patarimais, nutikimais, susidūrėte su paranormaliais, anomališkais ir kitais nekasdieniškais reiškiniais. Galite išversti iš užsienio kalbos, talpinkite su nuoroda. Laukiame Jūsų straipsnių, naujienų, apžvalgų ar istorijų!

Įvertink šį straipsnį. Prieš tai pakomentuodami, arba parašykite patys! Norėdami tobulėti, suteikiame jums galimybę įvertinti skaitomą PARANORMAL turinį. Norite sužinoti daugiau, sutikite gauti naujienas arba pasidalinkite spausdami .
Niekas neišdrįso palikti komentaro.
Būkite pirmi, kurie pasidalins savo nuomonėmis su kitais.
avatar
TAIP PAT SKAITYKITE:
04.12.2020 laikas 22:58 Johns-Hopkins researcher says CDC data show COVID-19 has NO effect on percentage of death in older people
When all is said and done, Americans — and the world — are going to discover that while the COVID-19 virus is real as was the pandemic, virtually nothing we’ve been told about the infection morbidity rates has been accurate....

Skaityti daugiau

04.12.2020 laikas 22:38 Election findings could ‘Easily’ overturn 3 states, data analyst concludes
WASHINGTON—The former data and strategy director for President Donald Trump’s 2016 election campaign says he has found enough evidence to suggest the election results could be “easily” turned to favor the current president....

Skaityti daugiau

04.12.2020 laikas 22:03 Moderna to start testing its mRNA COVID-19 vaccine on children – are parents really letting their kids serve as guinea pigs?
Moderna has announced that it will start testing its COVID-19 vaccine in children in a large, late-stage trial. The U.S. National Library of Medicine’s registry indicates that the study will include 3,000 participants aged 12 to 17....

Skaityti daugiau

04.12.2020 laikas 21:27 Namų vaistinėlė: Putinai gelbsti nuo peršalimo
Putinų arbatos skonis ir aromatas man pažįstami nuo vaikystės. Močiutė visada ruošdavo šį gėrimą, kai šeimoje kas nors susirgdavo peršalimo ligomis.

Skaityti daugiau

04.12.2020 laikas 21:04 Citrina prieš hipertoniją ir reumatizmą
Jei pajutote nemalonius pojūčius gerklėje, perštėjimą, neskubėkite griebtis medikamentų. Jums puikiai gali padėti citrinų nuoviras. Į nedidelį emaliuotą puodą išspauskite 3 citrinų sultis, truputį pašildykite ant mažos ugnies, nevirinkite....

Skaityti daugiau

04.12.2020 laikas 20:37 Namų vaistinėlė: 4 receptai nuo kosulio
ik kosuliui prasidėjus, padės imbieras, iš tarkuotos imbiero šaknies (1 šaukštas), citrinos ir medaus paruoškite arbatą. Ją gerkite kas 1-1,5 valandos. Sloga praeis po 1-2 stiklinių, o kosulys - po 5-6. Dar patartina sukramtyti česnako skiltelių....

Skaityti daugiau