Meniu
Asmeninė anketa Prisijungimas ir registracija
Atgal Pagrindinis » Autorių straipsniai » Medical Health » 2020 » Lapkričio » 16

Hydroxychloroquine does not help patients hospitalized with COVID-19: study

Hydroxychloroquine does not help patients hospitalized with COVID-19
  • 17.11.2020
  • 0.0 Reitingas
  • 663 Peržiūros
  • Aptarti

Findings from a national study published today in the Journal of the American Medical Association (JAMA) "do not support" the use of hydroxychloroquine for the treatment of adult patients hospitalized with COVID-19.

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) study found that, when compared to inactive placebo, hydroxychloroquine did not significantly improve clinical outcomes of patients hospitalized for respiratory illness related to COVID-19.

The study, which was funded by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, was conducted at 34 hospitals in the Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network.

"Hydroxychloroquine became a very commonly used medication for COVID-19 in the spring of 2020 without strong evidence that it would be beneficial," said the study's lead investigator, Wesley H. Self, MD, MPH, an emergency medicine physician and vice president for Clinical Research Networks and Strategy at Vanderbilt University Medical Center.

"Therefore, we conducted a clinical trial with the strongest methods possible to provide high quality information on whether hospitalized patients with COVID-19 should be treated with hydroxychloroquine," Self said. "Combined with other studies that showed similar findings, we believe this trial provides compelling data for clinicians to stop using hydroxychloroquine for hospitalized adults with COVID-19."

Some laboratory studies suggested hydroxychloroquine can inhibit replication of SARS-CoV-2, the virus that causes COVID-19. Observational studies early in the COVID-19 pandemic suggested that the drug may have beneficial effects for patients with COVID-19, which sparked great enthusiasm for hydroxychloroquine as a potential treatment.

However, clinical trials, which are considered the highest quality research studies for understanding the effect of a drug in patients, have failed to show beneficial effects of hydroxychloroquine for patients with COVID-19, Self said.

Between April and June 2020, 479 patients hospitalized for respiratory illness from COVID-19 were enrolled in the ORCHID study, a blinded, placebo-controlled randomized clinical trial.

Patients who were acutely ill and hospitalized with COVID-19 were treated with 10 doses of hydroxychloroquine or placebo over five days. The patient's clinical status, including hospital discharge, oxygen use, mechanical ventilator use and death, was followed for a month after the medication was started.

The study showed no evidence that hydroxychloroquine prevented death or helped patients recover from COVID-19 more quickly. One month after starting the study, 10.4% of patients treated with hydroxychloroquine and 10.6% of patients treated with placebo had died.

In June the NHLBI halted the study after determining that hydroxychloroquine was not likely to be of benefit to hospitalized patients with COVID-19.

"Our diverse teams of clinicians and research staff worked nimbly under extremely difficult circumstances to accomplish what the NIH and the PETAL Network do best: 'gold standard' studies of important questions for patients suffering from life-threatening conditions," said Samuel M. Brown, MD, MS, a critical care physician at Intermountain Healthcare and PETAL Network investigator who helped lead the trial.

"While we hoped that hydroxychloroquine would help, even this clearly negative result is critical as we work together to find effective treatments for COVID-19," Brown said.

"Having a rigorously designed clinical trial that captured patient-centered, clinically meaningful outcomes was critical to reaching the unequivocal conclusions about the use of hydroxychloroquine in COVID-19," said James P. Kiley, Ph.D., director, Division of Lung Diseases at NHLBI.

"ORCHID shows that hydroxychloroquine does not improve clinical outcomes in hospitalized COVID-19 patients," Kiley said. "We hope this clear result will help practitioners make informed treatment decisions and researchers continue their efforts pursuing other possible safe and effective treatments for patients suffering with this disease."

Turite savo nuomone, tapk autoriumi, prisijunk ir rašykite bloge. Dalinkitės receptais, sveikatos patarimais, nutikimais, susidūrėte su nekasdieniškais reiškiniais. Galite išversti iš užsienio kalbos, talpinkite su nuoroda. Laukiame Jūsų straipsnių, naujienų, apžvalgų ar istorijų!

Naujausias Pasaulio naujienas kitaip... skaitykite Paranormal Telegram kanale. Jei manai, kad mano darbas yra naudingas, pasidalink, prenumeruok, padėkok ar paremk...

Niekas neišdrįso palikti komentaro.
Būkite pirmi, kurie pasidalins savo nuomonėmis su kitais.
avatar

Nemokami skelbimai

TAIP PAT SKAITYKITE:
03.10.2023 laikas 23:20 Receptai | Patiekalai Skanus naminis vištienos troškinys
Nuo vištienos nuimkite odą, supjaustykite nedideliais gabalėliais, atskirkite mėsą nuo kaulų, sudėkite ją į puodą, pasūdykite, pagardinkite pipirais, naudokite bet kokius mėgstamus prieskonius. Puodą su mėsa apie 40 minučių padėki...

Skaityti daugiau

03.10.2023 laikas 08:23 Receptai | Patiekalai Paprastas mamos obuolių pyragas su grietinine tešla

Ganėtinai paprastas bei skanus pyragas; labiausiai čia tinka antaniniai obuoliai. Iš nurodyto kiekio iškepamas pyragas per visą didelę kepimo skardą. Jei norisi storesnio tešlos sluoksnio imame mažiau obuolių, tešlos plonai nek...

Skaityti daugiau

28.09.2023 laikas 10:19 Receptai | Patiekalai Traškūs avižiniai dribsniai su jogurtu ir keptais vaisiais
Itin skanus pasiūlymas Jūsų bene kiekvienos dienos pusryčiams - traškūs avižiniai dribsniais! Aš juos gaminu su šviežiais persikais ir abrikosais (tai mano kol kas labiausiai patikęs atrastas variantas), bet galite naudoti ir kons...

Skaityti daugiau

03.10.2023 laikas 22:42 Jei per lietų ar šaltį jus peršalote - skubios pagalbos receptas

Jums nebūtina iš karto griebtis tablečių. Yra natūralesnis ir skanesnis skubios pagalbos receptas jūsų sveikatai!

Skaityti daugiau

03.10.2023 laikas 10:20 Johno Kerry duktė įsakė vyriausybei iki 2030 m. masiškai eutanazuoti MILIJARDUS žmonių
Johno Kerio (John Kerry) dukra paragino pasaulio vyriausybes skubiai sustiprinti VŽV propagandą, kad visuomenės nariai būtų psichologiškai pasirengę stebėti milijardų žmonių mirtį, kurią pasaulinis elitas vykdys vykdydamas didįjį depopuliacijos vajų....

Skaityti daugiau

03.10.2023 laikas 09:04 Mirusių žmonių širdyse rastas mirtinas mRNA kiekis, rodo tyrimas
Naujame recenzuojamame tyrime nustatyta, kad mirusių žmonių, kurie mirė staiga sustojus širdžiai, širdyse aptinkamas mirtinai pavojingas mRNA kiekis.

Skaityti daugiau