Asmeninė anketa Prisijungimas ir registracija
Atgal » » » 2020 » Spalio » 19

Gut bacteria in multiple sclerosis: Probiotic or commensal, good or bad?

Gut bacteria in multiple sclerosis: Probiotic or commensal, good or ba

Researchers from the University of Vermont (UVM) have found that a bacterial species called Lactobacillus reuteri, commonly used in probiotics, can increase disease severity in a mouse model of multiple sclerosis (MS), an autoimmune disease that is the leading cause of non-traumatic neurological disability in young adults. But don't throw away your yogurt just yet.

Recent evidence suggests that the gut microbiome modulates risk of MS, but the specific bacterial species, and the role of host genetics, have not been clear. In many chronic diseases, scientists have found that the state of the gut microbiome is altered, which raised the possibility that restoring balance in the gut microbiome could treat or even prevent disease, and has further spurred the popularity of probiotic products, typically consisting of live bacteria with putative health benefits; presumably to "seed" or "restore" the gut microbiome.

The findings, published in the journal Proceedings of the National Academy of Sciences, highlight that complex interactions between host genetics and environmental factors drive susceptibility to multiple sclerosis, and suggest that antibiotic or probiotic strategies to prevent or treat multiple sclerosis should take into account host genetics, the pre-existing gut microbiome, and the timing or mode of the intervention.

"Our gut bacteria are part of a complex ecosystem that holds great potential for the prevention, treatment, and/or diagnosis of chronic diseases. However, many scientists have been going at it with a one-size-fits-all approach, and our research suggests that this is unlikely to work," said Dimitry Krementsov, who led the study. "Instead, a more personalized approach is needed."

Krementsov, assistant professor in the Department of Biomedical and Health Sciences at UVM, and researchers modulated the gut microbiomes of genetically diverse mice with high or low susceptibility to experimental autoimmune encephalomyelitis (EAE), a common animal model for multiple sclerosis. In order to determine which features of these microbiomes conferred higher susceptibility to MS-like disease, the researchers isolated different bacterial species from the complex mix and transferred them to new mice, one at a time.

The findings were surprising: one of the culprits identified was Lactobacillus reuteri, a normal commensal resident of the human and mouse gut that is also a widely used probiotic. This seemed to pinpoint this bacterium as the "bad guy," but the researchers also noted that this bacterium originally came from a genetically distinct mouse host that was normally resistant to MS-like disease. Hence, this suggests that the genetics of the host determines whether a particular microbiome state is "good" or "bad." The results of the study raise a critical question: are probiotics generally good or bad? The findings suggest that the answer is most likely dependent on the context, particularly on the individual who is receiving the probiotic.

The study authors point out caveats: they were not studying probiotics per se, but rather studying how normal commensal bacteria interact with the host. Probiotic bacteria are typically grown in a lab or food production facility and taken orally in massive daily doses. These probiotic bacteria are also genetically very distinct from their commensal counterparts, and the authors are currently exploring this possibility. Additionally, what is "bad" for an autoimmune disease like MS may actually be "good" in other contexts, like stronger immune response against infection. There are numerous examples of genes that promote "good" immune responses against infection or vaccination, but which in turn also result in a higher risk of autoimmune disease. Finally, other scientists have used high dose daily treatment with probiotic strains of Lactobacillus to reduce MS-like disease in mice, although recent studies show that the probiotic bacteria do not even need to be alive for this to work.

Thus, the answer is, probiotics may be good or bad, depending on the context. The next step is figuring out what this "context" actually is.

Turite savo nuomone, (už ar, prieš) pasidalinkite su mumis, palikite komentarą, prisijunkite, rašykite bloge, pasirinkdami kategoriją. Pasidalinkite savo receptais, sveikatos patarimais, nutikimais, susidūrėte su paranormaliais, anomališkais ir kitais nekasdieniškais reiškiniais. Galite išversti iš užsienio kalbos, talpinkite su nuoroda. Laukiame Jūsų straipsnių, naujienų, apžvalgų ar istorijų!

Įvertink šį straipsnį. Prieš tai pakomentuodami, arba parašykite patys! Norėdami tobulėti, suteikiame jums galimybę įvertinti skaitomą PARANORMAL turinį. Norite sužinoti daugiau, sutikite gauti naujienas arba pasidalinkite spausdami .
Niekas neišdrįso palikti komentaro.
Būkite pirmi, kurie pasidalins savo nuomonėmis su kitais.
01.12.2020 laikas 23:18 Legitimacy of Biden win buried by objective data

During the weeks following November 3, innumerable election experts and statistical analysts have pored over the voting data upon which former Vice President Joe Biden’s purported campaign victory ostensibly stands.


Skaityti daugiau

01.12.2020 laikas 23:05 Obama, Biden helped corrupt CCP-linked coronavirus testing firm come to the U.S.

During their occupation of the White House, Barack Obama and Joe Biden gave the green light to a Chinese Communist Party (CCP)-linked corporation to establish a presence in the United States where it is now trying to peddle Wuhan coronavirus (COVID-19) testing kits on Americans.


Skaityti daugiau

01.12.2020 laikas 23:05 Skeptical of voter fraud in 2020? Here’s your evidence.
Has anyone ever told you that “You can’t do it” and “You’re crazy” over and over? Perhaps they’ve told you this so many times, you’ve started to believe it yourself. This is what’s happening in our election today....

Skaityti daugiau

01.12.2020 laikas 20:49 10 paprastų aukštą kraujospūdį mažinančių produktų
Besiskundžiantiems padidėjusiu kraujospūdžiu ir sergantiems hipertenzija patariama vartoti produktų, kuriuose gausu kalio, nes kalis neutralizuoja žalingąjį druskos poveikį. Be to, naudinga vartoti produktų, kuriuose gausu magnio, vitamino C ir maistinių skaidulų....

Skaityti daugiau

01.12.2020 laikas 20:27 6 rudeniniai produktai, kurie organizme didina hemoglobino lygį

Žemas hemoglobino lygis būna todėl, kad organizme pernelyg mažai geležies. Norėdami padidinti hemoglobino lygį, rudenį gausiau vartokite sezoninių produktų.

Skaityti daugiau

01.12.2020 laikas 19:45 Kada jodas netinka gydyti skydliaukės ligas?
Jodas būtinas skydliaukės ligų profilaktikai, normaliam jos darbui, jei ji sveika.

Skaityti daugiau